The Yatsunyk lab is looking for a new Research Assistant. For more information and how to apply, click the link here.
Our laboratory focuses on non-canonical DNA structures, G-quadruplexes, i-motifs, and tandem repeats. Such sequences are found at telomeres and oncogene promoters, among other regions. Small molecule ligands strongly affect fold and stability of non-canonical DNA and may act as anticancer therapeutics. We strive to determine the structural details of DNA and DNA-ligand complexes and understand the reasons behind structural diversity of DNA. Our favorite techniques include X-ray crystallography, UV-vis and fluorescence spectroscopies, circular dichroism (CD), fluorescence resonance energy transfer (FRET), gel electrophoresis, and synthetic work.
If you are interested in working in the Yatsunyk lab:
send Liliya an email at lyatsun1
stop by her office in SC 286 or the lab SC 285
Lab News 2021
Liliya, Erin, and Kevin gave talks at the ACS Spring 2021 Virtual Meeting and Exposition. Liliya presented "Structure of T. thermophila telomeric DNA alone and with N-methylmesoporphyrin IX, NMM" on April 5th, Erin presented "Elucidating the structure of a four-repeat Satellite III DNA sequence” on April 7th, and Kevin presented "Water networks in G-quadruplexes" on April 14th.
Dana gave a poster presentation at the meeting, "Biophysical and structural characterization of Tetrahymena thermophila G-Quadruplexes alone and in complex with N-methyl mesoporphyrin IX."
The lab welcomed in the spring new students: Charlotte Pohl, Sara Yun, Tamanaa Atrafi, and Zahara Martinez.