Brigid Jensen

Education:

B.S. Biochemistry, Neuroscience; University of Pittsburgh

Ph.D. Neuroscience; University of Pennsylvania

Teaching:

Chem 010 (lab)

Research:

Selected publications:

1.   Russell KA, Shahrabi AA, Akerman SC, Byrne MD, Rothstein JD, Trotti D, Jensen BK, Haeusler AR. Intrathecal (G4C2)149 delivery in C9orf72-deficient mice yields mild motor dysfunction and ALS/FTD pathological hallmarks. Acta Neuropathol Commun. 2026 Jun 18. doi: 10.1186/s40478-026-02341-8. Epub ahead of print. PMID: 42316301.

2.   Copley KE, Mauna J, Danielson H, Chen Q, Ozguney B, Ngo M, Xie L, Smirnov A, Davis M, Mayne L,  Linsenmeier M, Rubien JD, Bergmann C, Portz B, Lee BL, Odeh HM, Lai L, Chang Y, Hallegger M, Ule J, Pasinelli P, Poon Y, Mittal J, Fawzi N, Black BE,  Donnelly C, Jensen BK, Shorter J. Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration. Science. 2026. 392, eadv3301. doi: 10.1126/science.adv3301.

3.    Jensen BK, Astrocyte-Neuron Interactions Contributing to Amyotrophic Lateral Sclerosis Progression. Adv Neurobiol. 2024; 39:285-318. doi: 10.1007/978-3-031-64839-7_12. PMID: 39190080.

4.   Jensen BK, McAvoy K, Heinsinger N, Lepore AC, Haeusler A, Trotti D, Pasinelli P. Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice. Glia. 2022 Jul;70(7):1426-1449. doi: 10.1002/glia.24183. PMID: 35474517.

5.   Jensen BK, Schuldi M, McAvoy KJ, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L, Haeusler A, Edbauer D, Pasinelli P, Trotti D. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. EMBO Mol Med. 2020 Apr 29. doi: 10.15252/emmm.201910722.