Welcome to the Yatsunyk Lab!
Our laboratory investigates the application of novel water-soluble porphyrins as potential anticancer agents. These porphyrins interact with telomeres in tumors and oncogenes promoters in a specific manner, leading to cell senescence or apoptosis. We want to understand the mechanism of these interactions. This knowledge will pave a way for new and selective anticancer treatments. Our favorite techniques include UV-vis, circular dichroism (CD), fluorescence resonance energy transfer (FRET), NMR, gel electrophoresis, and synthetic work. Most of the research is done by Swarthmore undergraduate students.
Wondering what we do outside of lab? Check out Yatsunyk lab doing things, our Tumblr!
Congratulations to Liliya on her recent publication!:
Yatsunyk, L. A.; Pietrement, O.; Albrecht, D.; Tran, P.L.T.; Renciuk, D.; Sugiyama, H.; Arbona, J.-M.; Aimé, J.-P., Mergny, J.-L. "Guided assembly of tetramolecular G-quadruplexes"
The paper will appear in ACS Nano June 2013.
Navin received a travel grant from French Government for his trip to Bordeaux, France this summer. Congratulations Navin!
Michelle was awarded the prestigious SURF (summer research fellowship) award from the American Chemical Society, Division of Organic Chemistry. Congratulations Michelle!
Steven got accepted to every graduate school he applied to and finally decided on Stanford!!!! Congratulations Steven!
Navin and Michelle attended the Thomas Jefferson University Sigma Xi Research day in Philadelphia, PA, on April 17, 2013. Michelle presented a poster entitled Synthesis and preliminiary characterization of polyamide derivatives of protoporphyrin-IX and mesoporphyrin-IX, and Navin presented a poster called N-methyl mesoporphyrin-IX as a sensitive reporter of strand orientation in guanine quadruplexes.
Jack received NSF Graduate Fellowship and NDSEG Graduate Fellowship from the Department of Defense in March 2013. Now he has to choose.
Our lab attended Swarthmore Sigma Xi poster session on October 26-27, 2012, and presented three posters focused on our summer research.
Our lab presented posters at the Haverford Undergraduate Research Symposium on September 22, 2012. Steven and Michelle gave an oral presentation regarding their research on the crystal structure of the NMM-Tel22 complex and the synthesis of novel amide porphyrin derivatives to students and faculty at the event.
Congratulations to Liliya on her publication in Biochemie:
Yatsunyk, L. A.; Bryan, T.; Johnson, F. B. "G-ruption: The third international meeting on G-quadruplex and G-assembly" Biochimie 2012, 94, 2475-2483.
Alessandro d'Urso (Ale) of the University of Catania visited the Yatsunyk lab on September 15, 2012 and presented his research on inducing chirality in porphyrin-DNA complexes. Lab members also gave short presentations and discussed exciting collaborations with Ale's lab.
Our lab attended the 244th American Chemical Society (ACS) National Meeting in Philadelphia, PA, on August 19 - 23, 2012. Vienna and Navin presented a poster titled "Investigation of the Interaction between DNA and Stabilizing Metallic Compounds" and Steven, Michelle, and Jack presented "Structural aspects of the interaction between human telomeric G-quadruplexes and N-methyl-mesoporphyrin IX."