Welcome to the Yatsunyk Lab!
Our laboratory investigates the application of novel water-soluble porphyrins as potential anticancer agents. These porphyrins interact with telomeres in tumors and oncogenes promoters in a specific manner, leading to cell senescence or apoptosis. We want to understand the mechanism of these interactions. This knowledge will pave a way for new and selective anticancer treatments. Our favorite techniques include UV-vis, circular dichroism (CD), fluorescence resonance energy transfer (FRET), NMR, gel electrophoresis, and synthetic work. Most of the research is done by Swarthmore undergraduate students.
Wondering what we do outside of lab? Check out Yatsunyk lab doing things, our Tumblr!
Congratulation to Navin, Josh and Liliya on their paper being accepted in FEBS J.
Sabharwal, N. C.; Savikhin, V.; Turek-Herman, J.; Nicoludis, John (Jack) M.; Szalai, V. A.; Yatsunyk, L. A. "N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes" accepted in FEBS J.
Congratulations to Liliya on her recent publication!:
Yatsunyk, L. A.; Pietrement, O.; Albrecht, D.; Tran, P.L.T.; Renciuk, D.; Sugiyama, H.; Arbona, J.-M.; Aimé, J.-P., Mergny, J.-L. "Guided assembly of tetramolecular G-quadruplexes" ACS Nano 2013, 7, 5701 - 5710.
Navin received a travel grant from French Government for his trip to Bordeaux, France this summer. Congratulations Navin!
Michelle was awarded the prestigious SURF (summer research fellowship) award from the American Chemical Society, Division of Organic Chemistry. Congratulations Michelle!
Steven got accepted to every graduate school he applied to and finally decided on Stanford!!!! Congratulations Steven!
Navin and Michelle attended the Thomas Jefferson University Sigma Xi Research day in Philadelphia, PA, on April 17, 2013. Michelle presented a poster entitled Synthesis and preliminiary characterization of polyamide derivatives of protoporphyrin-IX and mesoporphyrin-IX, and Navin presented a poster called N-methyl mesoporphyrin-IX as a sensitive reporter of strand orientation in guanine quadruplexes.
Jack received NSF Graduate Fellowship and NDSEG Graduate Fellowship from the Department of Defense in March 2013. Now he has to choose.