Welcome to the Yatsunyk Lab!
Our laboratory investigates how water-soluble porphyrins and other small molecule ligands interact with non-canonical tetrastranded DNA structures, quadruplexes, from telomeres and oncogenes promoters in a specific manner, leading to cancer inhibition. We want to understand the mechanism of these interactions as well as the structural details of quadruplexes alone and in complex with porphyrins. This knowledge will pave a way for new and selective anticancer treatments. Our favorite techniques include X-ray crystallography, UV-vis, circular dichroism (CD), fluorescence resonance energy transfer (FRET), NMR, gel electrophoresis, and synthetic work. Most of the research is done by Swarthmore undergraduate students. We have strong collaborations with researchers from UPenn, NIST, University of Louisville and from the European Institute of Chemistry and Biology in France.
Wondering what we do outside of lab? Check out Yatsunyk lab doing things, our Tumblr!
Welcome Barrett Powel, Sayed Malawi, and Deondre Jordan to Yatsunyk's lab in Spring 2015
Our lab hosted TBIC on December 7. Thomas gave a talk on his summer work
Congratulation to Thomas, Navin, and Jack on their paper being accepted in JBIC
Sabharwal, N.C.; Mendoza, O.; Nicoludis, J. M.; Ruan, T.; Mergny, J. -L.; Yatsunyk, L. A. “Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-Quadruplex DNA” Accepted in J. Biol. Inorg. Chem.