Welcome to the Yatsunyk Lab!
Our laboratory investigates how water-soluble porphyrins and other small molecule ligands interact with non-canonical tetrastranded DNA structures, quadruplexes, from telomeres and oncogenes promoters in a specific manner, leading to cancer inhibition. We want to understand the mechanism of these interactions as well as the structural details of quadruplexes alone and in complex with porphyrins. This knowledge will pave a way for new and selective anticancer treatments. Our favorite techniques include X-ray crystallography, UV-vis, circular dichroism (CD), fluorescence resonance energy transfer (FRET), NMR, gel electrophoresis, and synthetic work. Most of the research is done by Swarthmore undergraduate students. We have strong collaborations with researchers from UPenn, NIST, University of Louisville and from the European Institute of Chemistry and Biology in France.
Wondering what we do outside of lab? Check out Yatsunyk lab doing things, our Tumblr!
Our lab attended the third Philadelphia Inorganic Colloquium (PIC-3) on March 19 at the U. of Delaware (http://sites.temple.edu/picsite). Thomas Ruan presented a poster titled: "Interactions Between G-Quadruplex DNA and Porphyrin Ligands"; Alice, Sayed, and Barrett presented their poster titled: Interactions Between Non-canonical DNA and Ligands".
Congratulation to Liliya on her recent publication of "Blending quadruplexes and Bordeaux: a Grand Cru! The 5th International Meeting on Quadruplex Nucleic Acids, Bordeaux (France)" in Cell Chemical Biology (2016), http://dx.doi.org/10.1016/j.chembiol.2016.02.011
Welcome Barrett Powel, Sayed Malawi, Alice Liu, and Deondre Jordan to Yatsunyk's lab in Spring 2015
Our lab hosted TBIC on December 7. Thomas gave a talk on his summer work
Congratulation to Thomas, Navin, and Jack on their paper being accepted in JBIC
Sabharwal, N.C.; Mendoza, O.; Nicoludis, J. M.; Ruan, T.; Mergny, J. -L.; Yatsunyk, L. A. “Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-Quadruplex DNA” Accepted in J. Biol. Inorg. Chem.