Postdoctoral Fellowship, BMBCB, Northwestern University
Ph.D., Chemistry, University of Arizona
Honors Diploma, Chemistry, Chernivtsi State University, Ukraine
I teach Inorganic Chemistry (Chem 56) and an advanced seminar Topics in Bioinorganic Chemistry (Chem 106). In addition, I teach a General Chemistry Honors Course (Chem 10HN) and Advanced Integrated Experimental Chemistry (Chem 57) as well as laboratories in Biological (Chem 38L) and Organic Chemistry II (Chem 32L).
My laboratory focuses on the design, synthesis, and characterization of novel porphyrin-based antitumor drugs that function via inhibition of telomerase. The students will be exposed to various aspects of bioinorganic chemistry. They will get an opportunity to gain knowledge and experience in a broad range of techniques with multiple applications. These include basic and advanced synthetic skills, DNA manipulation, small molecules crystallization, collection/analysis of crystallographic data, and application of spectroscopic techniques (UV-vis, NMR, and CD) to characterization of porphyrin and porphyrin-G-quadruplex DNA interactions. The long term goal of the research is to contribute to the development of more potent porphyrin-based telomerase inhibitors.
(undergraduate researchers marked with *)
Sabharwal, N.C.;* Mendoza, O.; Nicoludis, J. M.;* Ruan, T.;* Mergny, J. -L. Yatsunyk, L. A. “Investigation of the interactions between Pt(II) and Pd(II) derivatives of 5,10,15,20-tetrakis (N-methyl-4-pyridyl) porphyrin and G-Quadruplex DNA” Accepted in J. Biol. Inorg. Chem.
Dong, D. W.; Filipe Pereira, F.; Barrett, S. P.*; Kolesar, J. E.; Cao, K.; Damas J. Yatsunyk, L. A.; Johnson F. B.; Kaufman, B. A. Association of G-quadruplex forming sequences with human mtDNA deletion breakpoints BMC Genomics 2014, 15, 677. doi:10.1186/1471-2164-15-677.
Yatsunyk, L. A.; Mendoza, O.; Mergny, J.-L. “Nano-oddities”: Unusual nucleic acid assemblies for DNA-based nanostructures and nanodevices Accounts of Chem. Res. 2014, 47, 1836-1844.
Sabharwal, N. C.*; Savikhin, V.; Turek-Herman, J. R.*; Nicoludis, J. M.*; Szalai, V. A.; Yatsunyk, L. A. “N-methylmesoporphyrin IX fluorescence as a reporter of strand orientation in guanine quadruplexes” FEBS J. 2014, 281(7), 1726-1737.
Renaud de la Faverie, A.; Guédin, A.; Bedrat, A.; Yatsunyk, L. A.; Mergny, J.-L. “Thioflavin T as a fluorescence light-up probe for G4 formation” Nucleic Acids Res. 2014.
Yatsunyk, L. A.; Pietrement, O.; Albrecht, D.; Tran, P.L.T.; Renciuk, D.; Sugiyama, H.; Arbona, J.-M.; Aimé, J.-P., Mergny, J.-L. "Guided assembly of tetramolecular G-quadruplexes" ACS Nano 2013, 7, 5701-5710.
To learn more about my research, please, visit my research group webpage.