A.B., Chemistry, Princeton University
Ph.D., Biophysical Chemistry, Yale University
Postdoctoral Fellow, Department of Chemistry, University of Pennsylvania
I have taught courses across the Chemistry curriculum, including Introductory Chemistry (Chem 1/10/10H), Physical Chemistry (Chem 44) and a number of Senior seminars (most recently, Chem 110). I also regularly mentor/supervise students engaged in research for credit (Chem 94/96/180).
The research in my lab focuses on the use of magnetic resonance spectroscopy to investigate the structural and dynamic properties of membrane-bound molecules. Membrane proteins (which comprise 25-30% of all proteins) carry out many important biological functions including transport of material across membrane and acting as receptors. We are interested in developing and applying nuclear magnetic resonance (NMR) and electron paramagnetic resonance (EPR) spectroscopic techniques to the study of membrane associated proteins.
Thomaston, J.L.*, Nguyen, P.A.*, Brown, E. C.*, Upshur, M.A.*, Wang, J. DeGrado, W.F. and Howard, K. P. (2013) "Detection of drug-induced conformational change of a transmembrane protein in lipid bilayers using site-directed spin labeling" Protein Science, 22 (1): 65-73.
Nguyen, P.A.*, Soto, C., Polishchuk, A., Caputo,G., Tatko, C., Ma, C., Ohigashi, Y., Pinto, L.H. DeGrado, W.F. and Howard, K.P. (2008) pH-Induced Conformational Change of the Influenza M2 Protein C-Terminal Domain. Biochemistry, 47, 9934-9936.
Zee, B.* and Howard, K.P. (2007) Probing the phase behavior of membrane bilayers using 31P NMR Spectroscopy. , Edited by D. Rovnyak and R. Stockland, Jr. American Chemical Society Symposium Series, Oxford University Press.
Duong-Ly*, K., Nanda, V., DeGrado, W., and Howard K.P. (2005) The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment. Protein Science, 14, 856-861.
Howard, K.P., Liu, W., Crocker, E., Nanda, V., Lear, J., DeGrado, W.F., and Smith, S.O. (2005) Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle. Protein Science, 14, 1019-1024.
Howard, K.P., Lear, J.D., and DeGrado, W.F. (2002) Sequence determinants of the energetics of folding of a transmembrane four-helix bundle protein. Proceedings of the National Academy of Sciences, 99(13), 8568-8572.
To learn more about my research please visit my research group webpage.