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Taylor Barrett

Visiting Assistant Professor

Chemistry & Biochemistry

Contact

  1. Email:tbarret1@swarthmore.edu
  2. Phone: (610) 957-6478
  3. Science Center 290
Taylor Barrett, Chemistry & Biochemistry

Education:

B.S., Chemistry, Rochester Institute of Technology;
Ph.D., Chemistry, Candidate August 2020, University of Pennsylvania.

Teaching:

Chem 48 (Biological Chemistry II)
Chem 58B (Computational/ Experimental Biochemistry)
Chem 118 (Special Topics in Biochemistry and Its Applications)

Research:

Research in my lab focuses on two main areas:

1.  Chemical techniques for protecting thioamide substitutions from unwanted side-reactions during solid-phase peptide synthesis and

2.  Utilizing unnatural amino acid mutagenesis in the expression of protein probes.

Recent publications:

*undergraduate coauthor

Barrett, T.M.; Chen, X.; Liu, C.; Giannakoulias, S.G.; Phan, H.A.T.; Wang, J*.; Keenan, E.K.*; Karpowicz R.J.; Petersson, E.J.; Studies of Thioamide Positional Effects on Serine Protease Activity Enable Two-Site Stabilization of Cancer Imaging Peptides. ACS Chem. Biol. (2020), 15, 3, 774-779. DOI:10.1021/acschembio.9b01036.

Barrett, T.M.; Fiore, K.E; Liu, C.; Petersson, E.J.; Thioamide-Containing Peptides and Proteins. Chemistry of Thioamides. T. Murai (Ed.) Springer Nature. (2019). DOI: 10.1007/978-981-13-7828-7.

Liu, C.; Barrett, T.M.; Chen, X.; Keenan, E.K*.; Petersson, E.J.; Fluorescent Probes for Studying Thioamide Positional Effects on Proteolysis Reveal Insight into Resistance to Cysteine Proteases. ChemBioChem 20 2059-2062 (2019) DOI:10.1002/cbic.201900115.