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Silvia Porello

Visiting Assistant Professor



  2. Phone: (610) 328-8608
  3. Science Center 292
Silvia Porello


B.S., Clinical Biochemistry, Universidad Nacional de Córdoba, Córdoba, Argentina
Ph.D., Biological Chemistry, University of Utah, Salt Lake City


Chem 108 Topics in Biochemistry
Chem 10 Lab




Recent Publications

"Immobilization of the glycosylphosphatidylinositol-anchored Gas1 protein into the chitin ring and septum is required for proper morphogenesis in yeast", Rolli, E, Ragni, E, Calderon, J, Porello, S, Fascio, U, and Popolo L., Molecular Biology of the Cell 2009, 20, 4856–4870.

"Escherichia coli apurinic-apyrimidinic endonucleases enhance the turnover of the adenine glycosylase MutY with G:A substrates", Pope, Mary Ann, Porello, Silvia L., and David, Sheila S., The Journal of Biological Chemistry 2002, 277, 22605-22616.

"Dissecting the enzymatic properties of damaged DNA repair by MutY", David, S. S., Porello, S. L., Chmiel, N. H., FASEB JOURNAL 1999, 13, 1458- 1458.

"Substrate Recognition by E. coli MutY using Substrate Analogs", Chepanoske, C., Porello, S. L., David, S. S., Nucleic Acids Research 1999, 27, 3197-3254.

"Single Turnover and Pre-Steady-State Kinetics of the Reaction of the Adenine Glycosylase MutY with Mismatch-Containing DNA Duplexes", Porello, S. L., Leyes. A. E., David, S. S., Biochemistry 1998, 37, 14756-14764.

"A Substrate Recognition Role for the [4Fe-4S]2+ Cluster of the DNA Repair Glycosylase MutY", Porello, S. L., Cannon, M.J., Davis S. S., Biochemistry 1998, 37, 6465-6475.

"Specific Recognition of a Substrate-based Inhibitor for the DNA Mismatch Repair Enzyme, MutY ", Porello S. L., Kuhn, H., Michaels, M. L., Davis, S. S., Journal of the American Chemical Society 1996, 118, 10684-10692.

"Physiological Analysis of Mutants Indicates Involvement of the Saccharomyces Cerevisiae GPI-Anchored Protein gp 115 in Morphogenesis and Cell Separation", Popolo, L., Vai, M., Gatti, E., Porello, S. L., Bonfante, P., Balestrini, R., Alberghina, L., Journal of Bacteriology, 1993, 175 (7), 1879-1885.