Liliya A. Yatsunyk
Postdoctoral Fellowship, BMBCB, Northwestern University
Ph.D., Chemistry, University of Arizona
Honors Diploma, Chemistry, Chernivtsi State University, Ukraine
I teach Inorganic Chemistry (Chem 046) and an advanced seminar Topics in Bioinorganic Chemistry (Chem 106). In addition, I teach a General Chemistry Honors Course (Chen 010H) as well as laboratories in Biological (Chem 038L) and Organic Chemistry II (Chem 032L).
My laboratory focuses on the design, synthesis, and characterization of novel porphyrin-based antitumor drugs that function via inhibition of telomerase. The students will be exposed to various aspects of bioinorganic chemistry. They will get an opportunity to gain knowledge and experience in a broad range of techniques with multiple applications. These include basic and advanced synthetic skills, DNA manipulation, small molecules crystallization, collection/analysis of crystallographic data, and application of spectroscopic techniques (UV-vis, NMR, and CD) to characterization of porphyrin and porphyrin-G-quadruplex DNA interactions. The long term goal of the research is to contribute to the development of more potent porphyrin-based telomerase inhibitors.
(undergraduate researchers marked with *)
Nicoludis, J. M.*; Miller, S.; Jeffrey, P.; Barrett, S. P.*; Rablen, P. R.; Lawton, T.; Yatsunyk, L. A. "Optimized end-stacking provides specificity of N-methyl mesoporphyrin IX for human telomeric G-quadruplex DNA" J. Am. Chem. Soc., 2012, 134 (50), 20446-20456.
Yatsunyk, L. A.; Bryan, T.; Johnson, F. B. "G-ruption: The third international meeting on G-quadruplex and G-assembly" Biochimie 2012, 94, 2475-2483.
Nicoludis, J. M.*; Barrett, S. P.*; Mergny, J.-L.; Yatsunyk, L. A. "Interaction of human telomeric DNA with N-methyl mesoporphyrin IX" Nucleic Acids Res. 2012, 40, 5432-5447.
Bhattacharjee, A. J.*; Ahluwalia, K.*; Taylor, S.*; Jin, O.*; Nicoludis, J. M.*, Buscaglia, R.; Chaires, J. B.; Kornfilt, D. J. P.; Marquardt, D. G. S., Yatsunyk, L. A. "Induction of G-quadruplex DNA structure by Zn(II) 5,10,15,20-tetrakis(N-methyl-4-pyridyl)porphyrin" Biochimie 2011, 93, 1297-1309.
Smith, J. S.; Chen, Q.; Garcia, M.; Yatsunyk, L. A.; Nicoludis, J. M.*; Garcia, M. S.; Monchaud, D.; Teulade-Fichou, M-P., Abramowitz, L.; Schultz, D.; Johnson, F. B. "Evidence for rudimentary telomere capping by G-quadruplexes in Saccharomyces cerevisiae" Nature Structural and Molecular Biology 2011, 18, 478-485.
Balasubramanian, R.; Smith, S. M.; Rawat S.; Yatsunyk, L. A.; Stemmler, t. L.; Rosenzweig, A. C. "Oxidation of methane by a biological dicopper center" Nature 2010, 465, 115-119.
To learn more about my research, please, visit my research group webpage