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In the phylum chordata, somites give rise to the skeleton and the development is dependent upon the expression of certain genes. For many species, such as mice, rats, and chickens, this gene has been determined to be Pax-1. We know that all chordates possess a set of genes that induces somite development. Since the development of the Zebrafish, Danio rerio, is similar in many ways to the development of other chordates such as mammals and birds, we will try to determine if valproic acid has similar effects on fish. By subjecting a number of Danioembryos to different concentrations of valproic acid, we will observe the embryo development for variations in the somite development, as well as if different concentrations of valproic acid affect the development of the embryos in general.

© Cebra-Thomas, 2001

Last Modified: 31 May 2001

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