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The Role of Fibroblast Growth Factor 10 (FGF10) on the Branching

Morphogenesis in Embryonic Chick Lungs

Matthews Banda, John K. De Long IV, & Jessica Kaiser


It has been shown that FGF10 has a significant role in the branching morphogenesis in the embryonic mouse lung (Bellusci

et al., 1997; Weaver et al., 2000). During embryonic mouse lung morphogenesis, the distal mesenchyme regulates the growth and

branching of adjacent endoderm. It was reported that Fibroblast Growth Factor 10 (FGF10) is expressed dynamically in the

mesenchyme adjacent to the distal buds from the earliest stages of lung development (Bellusci et al., 1997). Results from out

experiment suggest that FGF10 acts in the same role in embryonic chick lungs as it does in mice development. By using an

FGF10 inhibitor on 6-day-old chick lungs we observed that formation of further lung buds does not occur as it normally would.

By using FGF10 loaded heparin beads we were able to induce the production of new lung buds in 6-day-old chick embryos.

© Cebra-Thomas, 2001

Last Modified: 31 May 2001

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