Science Center 286
Telephone: (610) 328-8558
My laboratory focuses on the design, synthesis, and characterization of novel porphyrin-based antitumor drugs that function via inhibition of telomerase. The students will be exposed to various aspects of bioinorganic chemistry. They will get an opportunity to gain knowledge and experience in a broad range of techniques with multiple applications. These include basic and advanced synthetic skills, DNA manipulation, small molecules crystallization, biological molecules crystallization, collection/analysis of crystallographic data, and application of spectroscopic techniques to characterization of porphyrin and porphyrin—G-quadruplex DNA interactions. The long term goal of the research is to contribute to the development of more potent porphyrin-based telomerase inhibitors.
Last Update: 6.15.08 David Marquardt '08
Created: 10.21.07 David Marquardt '08
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