KATHLEEN P. HOWARD (short form CV)

 

Department of Chemistry and Biochemistry                                                           

Swarthmore College                                                                                                  

500 College Avenue                                                                                     

Swarthmore, PA 19081-1397

 

PROFESSIONAL EXPERIENCE

Swarthmore College, Swarthmore, Pennsylvania
Professor, Department of Chemistry and Biochemistry, 2011-present
Chair, Department of Chemistry and Biochemistry, June 2009-August 2011
Associate Professor, Department of Chemistry, 2003-2011

Assistant Professor, Department of Chemistry, 1997-2003

 

University of Pennsylvania, Philadelphia, Pennsylvania

Adjunct Associate Professor of Biochemistry and Biophysics, July 2003-present

Visiting Faculty, Department of Biochemistry and Biophysics, Fall 2000-Fall 2001

 

University of Pennsylvania, Philadelphia, Pennsylvania

Postdoctoral fellow in the Department of Chemistry, 1995-1997

Recipient of a Arthritis Foundation Postdoctoral Fellowship

Advisor:  Dr. Stanley Opella

 

EDUCATION

Yale University, New Haven, Connecticut 

Ph.D. in Biophysical Chemistry, May 1995

Advisor:  Dr. James Prestegard

NMR Studies of the Structure/Dynamics of Membrane-Bound Diacylglycerol Glycolipids

 

Princeton University, Princeton, New Jersey

A.B. cum laude in Chemistry, May 1990

 

AWARDS/HONORS

Henry Dreyfus Teacher Scholar 2005-2010, NSF CAREER Award 2001-2006, Eugene M. Lang Faculty Fellow 2000-2001, Sigma Xi 1997, Yale Department of Chemistry Excellence in Teaching Award 1995, Samuel K. Bushnell Graduate Fellowship 1992, National Research Service Award 1991

 

SWARTHMORE COURSES TAUGHT

•  Chemistry 1 - Chemistry in the Human Environment

•  Chemistry 3/9/10/10H - General Chemistry

•  Chemistry 44/45 - Principles of Physical Chemistry I and II

•  Chemistry 50 - Modern Instrumental Methods in Chemistry and Biochemistry

•  Chemistry 94/96/180  - Research Project/Thesis/Honors Thesis

•  Chemistry 105 - Theory and Applications of Spectroscopy

•  Chemistry 110 - Advanced Topics in Biophysical Chemistry


PUBLICATIONS
(undergraduate co-authors)

 

1. Ram P., Kim E., Thomson D., Howard, K.P., & Prestegard J.H. (1992) Computer Modeling of Glycolipids at Membrane Surfaces. Biophysical Journal, 63, 1530-1535.

 

2. Gosser, Y., Howard, K.P., & Prestegard, J.H. (1993) Three Dimensional 1H-Detected 13C-13C Correlation Experiments for Carbon Backbone Assignments of Enriched Natural Products. Journal of Magnetic Resonance B, 101, 126-133.

 

3.  Chung, J., Tolman, J.R., Howard, K.P., & Prestegard, J.H. (1993) Three Dimensional 13C-13C Correlated Experiments on Oligosaccharides. Journal of Magnetic Resonance B, 102, 137-147.

 

4.  Hare, B.J., Howard, K.P., & Prestegard, J.H. (1993) Torsion Angle Analysis of Glycolipid Order at Membrane Surfaces. Biophysical Journal, 64, 392-398.

 

5.  Sanders, C.R., Hare, B., Howard, K.P., & Prestegard, J.H. (1993)Magnetically-Oriented Phospholipid Micelles as a Tool for the Study of Membrane-Associated

Molecules. Progress in NMR Spectroscopy, 26(5), 421-444.

 

6.  Metz, G., Howard, K.P., van Liemt, W.B.S., Prestegard, J.H., Lugtenburg, J., & Smith, S.O. (1994)  NMR studies of ubiquinone location in oriented model membranes:  Evidence for a single motionally-averaged population. Journal of the American Chemical Society, 117, 564-565.

 

7. Martin, K.S., Royer, C.A., Howard, K.P., Carey, J., Liu, Y., Matthews, K., Heyduk, E., Lee, J.C. (1994) Electrostatic Forces Contribute to Interactions Between trp repressor Dimers. Biophysical Journal, 66, 1167-1173.

 

8. Howard, K.P. & Prestegard, J.H. (1995) Conformation of Monogalactosyl Diacylglycerol at the Surface of Magnetically-Oriented Phospholipid Bilayers. Journal of the American Chemical Society, 117, 5031-5040.

 

9.  Howard, K.P. & Prestegard, J.H. (1996)  Conformation of Sulfoquinovosyl Diacylglycerol at the Surface of Magnetically-Oriented Phospholipid Bilayers. Biophysical Journal, 71, 2573-2582.

 

10.  Howard, K.P. & Prestegard, J.H. (1996)Conformation and Dynamics of Digalactosyl Diacylglycerol. Journal of the American Chemical Society, 118, 3345-3353.

 

11.  Howard, K.P. & Opella, S.J. (1996)  High Resolution Solid State NMR of Integral Membrane Proteins Reconstituted into Magnetically Oriented Phospholipid Bilayers. Journal of Magnetic Resonance, 112, 91-94. 

 

12. Garber, S.M., Lorigan, G.A., and Howard K.P. (1999) Magnetically Oriented Phospholipid Bilayers for Spin Label EPR Studies. Journal of the American Chemical Society, 121, 3240-3241.

 

13. King, V. , Parker, M. and Howard, K.P. (2000) Pegylation of Magnetically Oriented Lipid Bilayers. Journal of Magnetic Resonance, 142 (1), 177-182.

 

14. Howard, K.P. (2000) Thermodynamics of DNA Duplex Formation. Journal of Chemical Education, 77(11)1469-1471.

 

15. Mangels, M., Cardon, T., Harper, A. Howard, K.P. and Lorigan, G.A. (2000) Spectroscopic Characterization of Spin Labeled Magnetically Oriented Phospholipid Bilayers by EPR Spectroscopy. Journal of the American Chemical Society, 122(29), 7052-7058.

 

16. Cardon, T.B., Tiburu, E., Padmanabhan, A., Howard, K.P. and Lorigan, G.A. (2001) Magnetically Aligned Phospholipid Bilayers at the Parallel and Perpendicular Orientations for X-Band Spin-Label EPR Studies. Journal of the American Chemical Society; 123(12), 2913-2914.

 

17. Parker, M., King, V. and Howard, K.P. (2001) NMR study of doxorubicin binding to cardiolipin containing magnetically oriented phospholipid bilayers. Biochimica Biophysica Acta – Biomembranes, 1514(2), 206-216.

 

18.  Mangels, M., Harper, A., Smirnov, A.I., Howard, K.P. and Lorigan, G.A. (2001) Investigating Magnetically Aligned Phospholipid Bilayers with EPR Spectroscopy at 94 GHz. Journal of Magnetic Resonance, 151, 253-259.

 

19. Howard, K.P., Lear, J.D., and DeGrado, W.F. (2002)  Sequence determinants of the energetics of folding of a transmembrane four-helix bundle protein.  Proceedings of the National Academy of Sciences, 99(13), 8568-8572.

 

20. Howard, K.P., Liu, W., Crocker, E., Nanda, V., Lear, J., DeGrado, W.F., and Smith, S.O. (2005)  Rotational orientation of monomers within a designed homo-oligomer transmembrane helical bundle. Protein Science, 14, 1019-1024.

 

21. Duong-Ly, K., Nanda, V., DeGrado, W., and Howard K.P.  (2005) The conformation of the pore region of the M2 proton channel depends on lipid bilayer environment.  Protein Science, 14, 856-861.

 

22. Zee, B. and Howard, K.P. (2007) "Probing the phase behavior of membrane bilayers using 31P NMR Spectroscopy" in Modern Nuclear Magnetic Resonance in Undergraduate Education, Edited by D. Rovnyak and R. Stockland, Jr. American Chemical Society Symposium Series, Oxford University Press.  (invited and peer reviewed)

 

23. Nguyen, P.A.,  Soto, C.,  Polishchuk, A., Caputo,G., Tatko, C.,  Ma, C., Ohigashi, Y., Pinto, L.H. DeGrado, W.F. and Howard, K.P.  (2008)  pH-Induced Conformational Change of the Influenza M2 Protein C-Terminal Domain.  Biochemistry, 47, 9934-9936. 

     

24.  Saotome, K.,  Duong-Ly, K. and Howard, K.P. (2011) M2 protein conformation and dynamics depends on model membrane.  In preparation for submission.     

 

PROFESSIONAL ACTIVITIES

Reviewer for Journal of the American Chemical Society, Proceedings of the National Academy of Sciences, Biochemistry, Biophysical Journal, Journal of Magnetic Resonance, Journal of Physical Chemistry,  Protein Science, Biochimica Biophysica Acta, Concepts in Magnetic Resonance, Analytical Biochemistry and Journal of Chemical Education

 

National Scientific Committees: Review Panel for NSF Graduate Research Fellowship Panel, NSF Review Panel for CREF-MU Instrument Acquisition, NSF Review Panel for MRI and Chemical Instrumentation.

 

Testified as a Witness for a Congressional Hearing:  "Meeting the Demands of the Knowledge Based Economy:  Strengthening Undergraduate Science, Mathematics and Engineering Education" Committee on Science, US House of Representatives, Washington, DC.  (March 2002)

 

Postdoctoral supervisor/mentor for the Teaching Postdoctoral Fellowship Program at Swarthmore College funded by HHMI, 2007-2008.

 

Workshop presenter for "Expand your Horizons" program at Swarthmore College designed to encourage girls to consider careers in the physical sciences.  (April 2005, March 2006, March 2007, March 2008, March 2010)

 

Participated in Summer Science Outreach Program for middle school students (Chester Children's Chorus Program) (Summers 2005 - 2011)

 

Education Committee, National Biophysical Society (2000–2003):  Edited the Society's pamphlet titled "Careers in Biophysics" for high school/college students contemplating a scientific career.


Member of Sigma Xi, Biophysical Society and American Chemical Society