Figure 13-5a

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The X-ray structure of the tyrosine kinase domain of the insulin receptor. The N-terminal domain is pink and the C-terminal domain is cyan with its activation loop light blue. The three Tyr side chains that are autophosphorylated, most probably by the opposite subunit, are drawn in stick form and the ATP analogue AMPPNP is shown in space-filling form, all with C green, N blue, O red and P yellow. The peptide substrate is colored orange with its phosphorylatable Tyr residue drawn in stick form with C magenta and O red. [Based on an X-ray structure by Stevan Hubbard, New York University Medical School, PDB 1IR3]