Figure 18-22a


Figure 18-22b



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X-ray structures of F1-ATPase from bovine heart mitochondria. (a) F1-ATPase in complex with ADP and ATP drawn as a semitransparent ribbon diagram viewed parallel to the membrane with the matrix above. The α, β, γ, δ and ε subunits are pink, yellow, blue, orange and green, respectively, and the nucleotides are shown in space-filling form with ATP C green, ADP C cyan, N blue, O red, and P orange. (b) The structure in Part a is rotated 90° about the horizontal axis such that the protein is viewed along its pseudo-3-fold axis from the matrix. Click on the "Show" and "Hide" to alternately visualize the ATPs and the ADPs. Note that although the αTP and βTP subunits (middle right and upper right of Part b) both normally bind ATP, in this structure they have bound ADP. [Based on an X-ray structure by Andrew Leslie and John Walker, MRC Laboratory of Molecular Biology, Cambridge, U.K. PDBid 1E79.]